We meet the Stratford sisters, Kat and Bianca, two very different people with very different views in life. They start at a new high school Padua High School with one thing in common, they both know strategy is the key. Kat wants to save the world and get out of high school as fast as she can, while Bianca wants to climb the ladder of high school popularity as fast as possible. Can each sister find happiness after getting off to a very rocky start?
Bianca arranges a charity event for the cheerleading squad to impress Chasity. But her plan ends up raising more questions than money. Will Bianca get her flowers? Will Cameron ever get the guts to express his feelings? While Bianca waits for her carnations to arrive, Kat deals with a stalker and wonders in secret whether Patrick will send her a carnation.
Kat learns that first impressions aren't everything when she makes a shocking discovery about Patrick. Meanwhile, Bianca decides that it's time to rid herself of her squeaky clean persona. To do this, she starts a rumor about her recent conquests with an older guy. After hearing all of the rumors, Cameron's feelings are instantly hurt.
Kat tries to break the stereotype of girls doing everything a boy can do by joining a class to fix cars. Bianca and Joey become lab partners. Chastity makes a deal with Bianca for the top spot as a cheerleader provided Joey passes his Chemistry paper and plays for the team.
Bianca and her new friend Dawn ask Cameron to help them with a new web reality show, so that Bianca can go in a shopping trip with Chastity. In order to get more viewers the girls realize that they need to be a little more adventurous. How far will they go to raise the money? Meanwhile, Kat complains about the grading system in one of her classes. Luckily for Kat, the school counselor has a personal vendetta against this particular teacher. In the end, the whole experience leads Kat to some self-realizations that she did not expected.
Bianca tries to us another opportunity to impress Chastity, when local residents suffer a bushfire and are relocated to Padua High. She tries to find a private room for Chastity in the school. Meanwhile, Patrick tries to have a moment alone with Kat to confess his feelings, but with the panic of the fire his chances might be ruined. They finally find a moment alone together in the school rooftop. Can Patrick get to tell her how feels?
When the soccer team captain, Beau Bradley asks Bianca go with him to Padua High's Fall Fling, she tries to convince Patrick to take Kat to the dance because her father will not let her go on a date until Kat does. Will Patrick help Bianca out?
Meanwhile, Cameron overhears Beau talking about taking Bianca to a hotel after the dance, so he devices a plan to keep an eye on Bianca at all times and don't let Beau make his moves.
Kat and Bianca fight for their right to party. At the party Chastity and Joe have some problems of their own regarding their relationship. Patrick attempts to make amends with Kat after he deserted her at the dance.
Kat stages a protest after Padua High enforces a new security policy and school uniforms, while Cameron has a hard time getting over Bianca who is sneaking around with newly single Joey.
In the mid-season premiere episode, Kat and Patrick are caught skipping school and both get suspended. How will Kat deal with a suspension after learning it might ruin her GPA, potentially destroying her dream to get into a prestigious college? Meanwhile, Bianca has her own problems after a secret make-out session with Joey is caught on video. Will Chastity watch the security tape before Bianca gets the chance to erase the evidence?
Dr. Stratford wants Kat to invite Patrick over dinner and a healthy helping of interrogation. Meanwhile, all the cheerleaders freeze Bianca out, and Chastity says there's just one way she can have all her friends back.
Kat tries to institute Meatless Mondays to change the world for the better. She is joined by Blank a british handsome guy and Patrick is jealous. Meanwhile, Bianca is determined to find Cameron a girlfriend but Cameron is finding hard to just be friends with Bianca. Walter decides to start dating again and joins an online dating service.
Bianca, tries to take Padua Hight's talent show until Chastity steels her song. Then right before going on stage, Chastity has tecnical difficulties and her mom tells her to drop out of the show. Will Chastity perform or will Bianca win the talent show and the grand prize of a walk-on role on "Make It or Break It"? Meanwhile, Cameron performs a magic act with a stage-struck Kat at his side.
Patrick starts to act more mysterious than usual and Kat thinks he has done something bad, while Joey wants to be in "The Next Biggest Poser" a male modeling reality TV show. Kat then spies on Patrick with the help of Cameron.
It's movie night at Padua High, and Bianca sets Cameron up on a date with Dawn so that they can double date with her and Joey. Meanwhile Kat is upset that Patrick told her she can date anyone she likes, so she decides to accept Blank's date night invitation. Patrick doesn't deal well with seeing Kat with the other guy, while Walter hits it off with the school counselor, and romance ensues.
Kat and Patrick make a major relationship decision. Walter asks the school counselor, Mrs. Tharpe out on a date, and Cameron's best friend Michael, comes out of the closet. Meanwhile, Bianca plans a fancy dinner party at home for her friends, and Joey gets a callback from "Biggest Poser".
Kat and Bianca discover that Walter is dating their school counselor, Darlene, and Kat decides to study abroad in Nepal, to try to get over Patrick. Bianca has to deal also with missing Joey while he is sequestered at the "Biggest Poser" house. Meanwhile, Cameron writes a love poem to Dawn, to express his love for her.
Kat decides to run for student body president after she learns William (Blank) is running unopposed. However, someone sabotages her video presentation and Kat ends up being humiliated. Bianca learns that playing nice is not always the best option.
