Dr. William Masters, Washington University’s foremost OB/GYN, runs a successful medical practice by day and conducts a secret study of human sexuality by night. Former nightclub singer Virginia Johnso…

On the heels of Masters’ proposal that they participate in the sexual response study, Johnson considers the best course of action to keep her job – only to find she no longer has one. The study has be…

Masters and Johnson continue their research in the brothel but skewed data confirms that Masters must get the study back into the hospital. At the hospital, Johnson is surprised to learn that a distin…

With the study back in the hospital, Masters and Johnson recruit new participants on campus. But Johnson is shocked when her ex-husband George, who’s crashing on her couch, wants to sign up. Masters’ …

When Masters and Johnson expand the study to include couples, they discover that the science of sex is easily complicated by the mystery of attraction. Johnson tries to connect with her son who prefer…

In the aftermath of the miscarriage, Libby and Masters travel to Miami for some much needed rest and relaxation, but Masters is drawn back into his work by a sexually adventurous couple next door. Alo…

Masters and Johnson continue their sexual response study – now as participants – but Johnson fears their work may be interfering with Masters’ home life. Libby pressures Dr. Haas to resume her fertili…

Masters and Johnson decide that the best way to record their study findings is to film them, but to do so they have to enlist outside help. Johnson redoubles her efforts to get a college degree, only …

When Masters and Johnson decide to film external reactions in the study, they must convince Lester and Jane that their footage won’t cross the line into pornography. Haas and Vivian’s plans for a Pres…

The hospital takes part in a nationwide civil defense drill, and the heightened atmosphere escalates conflicts among the staff. A former study participant reveals she’s pregnant and wants to know the …

With Johnson no longer on his team, Masters accepts Libby’s offer to help compile the study work for a hospital-wide presentation. But when Masters sees another doctor’s presentation put his colleague…

Masters’ work on human sexuality culminates with a hospital-wide presentation of his and Johnson’s research findings. But when Masters attempts to push the envelope with the external footage of the fe…

Masters deals with the ramifications of his disastrous presentation and being fired from the hospital. Meanwhile, Libby urges Masters to get another job; and Virginia fights off advances and innuendos…

Masters begins a new job at Memorial Hospital under Betty's extortion terms only to discover that his boss insists he leave Virginia behind in favor of a handpicked secretary. Meanwhile, Johnson is to…

Masters delivers a baby with ambiguous genitalia and urges the parents not to surgically assign the child a sex out of fear or convenience. Meeting Virginia at a hotel for a secret rendezvous, the two…

Langham observes Masters and Johnson exiting a hotel room and shares his suspicions with DePaul, who is forced to make plans for her work without Virginia's involvement. Meanwhile, Betty attempts to c…

Masters continues to break new ground by continuing his study as the only white physician in a Negro hospital but at the cost of his gynecology practice. Libby is confronted by Coral's boyfriend, Robe…

After Hendricks bans Masters from using black participants in his study, Masters contacts a journalist to promote his efforts, using the debunking of sexual stereotypes as the lure. Johnson is forced …

In the wake of Masters' discovery that Johnson has continued to have romantic relationships with other men, he becomes impotent without her knowledge and cuts off their sexual work together. He tries …

Masters privately treats a couple for infertility, without revealing his relationship to them. Johnson realizes her work with Masters can be used to help people suffering from sexual dysfunction - but…

Virginia continues to impersonate a patient's case history in order to glean advice from a psychiatrist. Betty and Masters' attempt to remedy Lester's impotence by hiring a prostitute rattles him even…

Masters learns of a rival study and calls in a public relations expert to help brand his work with Johnson. Virginia, having finally learned of Masters' sexual difficulties, is invigorated by the pros…

A television crew arrives at the clinic to document Masters and Johnson's work treating sexual dysfunction. Masters considers the publicity premature, and himself unsuitable as a television presence. …

After watching an early cut of the documentary, Masters is disturbed by the portrayal of his work. Johnson's move to solidify her custody arrangement with George backfires. Finding justification in Ma…

Masters and Johnson face the press for the first time.

Masters takes on a high profile patient. Virginia and Libby come to terms.

Masters and Johnson look to capitalize on their burgeoning fame.

Masters seeks unexpected advice. Virginia is distracted by news of Henry.

Johnson's parents arrive unannounced. Masters takes on a promising patient.

Masters and Johnson take on a famous couple hoping to renew their sex life.

Masters and Johnson are interviewed as they take on an exotic new patient.

Johnson jets away with Dan Logan. Masters begins his surrogacy program.

Masters continues his surrogacy program, now under Johnson's critical eye.

Johnson objects to Masters' program following missteps in the protocol.

Agendas collide as Masters, Johnson, Logan and his wife meet for a dinner.

Masters and Johnson find their life's work in jeopardy. Season finale.

In the wake of their fallout, Masters and Johnson search for purpose in a world without one another and look to work as their personal lives crash down around them. Libby finds herself alone for the f…

Masters and Johnson turn to new partners in an effort to put the past behind them and focus on their expanding clinic. Given their fractured triangle, Libby reevaluates her relationship with Bill and …

Masters and Johnson adjust to new partners, but their respective cases have them second-guessing the instinct to remain separated. A romantic prospect pushes Libby to embrace life as a newly single wo…

Johnson, Masters, Libby and Keller wind up together at a party thrown by Art and Nancy. Pairings and perspectives shift as the night wears on, until the light of day exposes the consequences of the ev…

Johnson and Masters' troubles come to a head as the trial begins with Keller leading the charge. Virginia does her best to revive their career as Bill faces the reality of what the charges could mean …

Johnson looks to get her relationship with Masters back on track while Masters does his best to find satisfaction elsewhere. Betty and Helen ready themselves for a new addition; Art and Nancy discuss …

Masters looks to groom Art as his protege in a new area of research as Johnson does her best to keep Nancy at arm's length. Betty seeks an unlikely source for assistance in her fight for equal rights …

Masters and Johnson go on the road and pose as a couple to investigate practices at a competing clinic. While Bill and Virginia are away, Art, Nancy and Langham take advantage of their absence to furt…

Masters and Johnson return from Topeka, each grappling with the trip's ramifications. Art and Nancy look to tie up loose ends in order to have a fresh start, and Libby embarks on a road trip with Bram…

Masters and Johnson work to save the practice from disintegrating in the face of insurrection within the clinic. As everyone in their lives either moves on or falls away, Bill and Virginia find solace…