Veteran reporter Roberto and rookie Meryl find themselves helping Vash the Stampede, an infamous thief with a bounty of six million double-dollars on his head.

Vash is in danger again now that ordinary townsfolk who have heard about the bounty are after him. As Vash tries to leave town, he runs into a family of heinous criminals who have broken out of prison…

Vash, the town of Jeneora Rock, and the Nebraskas reach a three-way truce, but their brief moment of peace is shattered by yet another assailant. He seems to be after the plant as well, but something …

Vash meets Nicholas, a suspicious undertaker who carries a huge cross. Before they could get to know each other, though, they are attacked by a huge worm, swallowing them and the building they were in…

Vash is drawn towards a seemingly abandoned village with a giant windmill, for reasons that only he knows. There, the group is attacked by a tremendous gale of gunfire.

Vash and Wolfwood board the massive Sandsteamer vessel to travel to their final destination, JuLai. Yet again, they are ambushed by a hail of gunfire, but this time, it's someone Wolfwood knows.

Vash and Wolfwood work together to stop Livio, an assassin who has lost his sense of self. The chaos is further accelerated by an attack by the Bad Lads Gang. While this is happening, someone sabotage…

Many years in the past, a colony ship traveling through space to find a new home for humanity suddenly experienced an emergency. Young Vash and Knives were saved by Rem and crash-landed on the planet …

After surviving the crash, Vash started a life with Luida and Brad, while Knives formed an alliance with Conrad, the leader of the research group called the Sinners. The twins finally meet again in fr…

Meryl and Roberto are taken to JuLai, the Third City, by Zazie. There, they learn why and how the human race ended up on this planet, No Man's Land. They also see Conrad, the former leader of the Sinn…

Caught in Knives' trap, Vash is dropped into a giant pool. There, Knives attacks the precious memories that helped Vash maintain his love towards humanity. While Vash and Knives clash in this metaphys…

Two years have passed since the events at JuLai. Vash is still missing. Someone is stealing Plants again.

When their home is attacked, Vash is the last hope for Brad, Jessica, and the others.

The immediate threat is suppressed, but now there is no doubt that the threat from Knives is still real.

Vash sets off for Home with his companions, but Knives' men are already planning a new attack.

Midvalley attacks Home and faces off against Wolfwood.

Everyone prepares for a huge battle as Legato and the Ark approaches Ship 3.

As the arrival of the fleet imminent, both factions begin preparations for the final showdown.

Wolfwood helps Vash break out of the Ark, but is pursued by Razlo, Livio's alter ego.

The crew, with its latest new member Livio, regroup at Hopeland to kick off their plan to stop Knives.

Vash and Knives, and their respective allies, face off in a final showdown at the crash site where it all started.

Knives arrives and captures Vash. His final plan is set in motion - as well as Vash's final resistance.