Spot mistakenly believes she has only until nightfall to live. Knowing better, the Trio takes this as an opportunity to get her to live life to the fullest.
Lonely Cruella thinks Roger's fancy valentine for Anita is for her instead, while Horace and Dumpling try to find love with a reluctant Nanny and Lucky.
Cruella claims to have spotted the rare solitary tree shrewzle on Dearly property. So the Dearly's must sell the farm to Cruella for her to convert it to a shrewzle sanctuary.
Cruella downsizes Anita so that she'll then work for Ralphie. Then she has P.H. DeVil kidnap Rolly and replace him with a robot double to spy on Anita's work.
Cruella's art critic friend Leticia judges some paint marks Spot makes as great art. So Spot becomes excited at the possibility that she might be a genius artist.
Pug puts Rolly through a tough endurence test in an effort to get him kicked out of the Bark Brigade. But Rolly's expert tracking ability will save him.
Lucky cuts his head while doing a dare by Mooch. He has to wear a cone to prevent him from tearing at his stitches. Mooch and others constantly tease him.
When Lucky's horseshoe spot pattern rubs off, he believes he has lost all his luck along with it. Meanwhile, Cruella tries to sabotage Roger's newest computer game.
Cadpig and Mooch fall in love, although Cadpig's only aim is to persuade him not to fight in a wrestling match against El Diablo. However, despite Cadpig's controlling of him, Lucky, Rolly, and Spot want him to fight, and attempt to help him get up to shape for the fight.
Cruella takes over the Kanine Krunchies brand of dog food and starts making it out of sawdust. Soon, however, Rolly discovers the plan and tries to stop it with the help of his friends.
Spot wishes she was a dog. Drumstick, her fairy god-chicken, shows up to grant her wish. Soon, however, Spot gets more than she bargained for when she discovers that being a dog has many disadvantages.
While Pongo, Perdita, and the humans are away, Cadpig discovers she has PDS, and Swamp Rat takes over the house for his party. The pups, with Lt. Pug, try to drive him out.
Roger plans a second honeymoon trip for him & Anita to renew their wedding vows. But the Dearlys wind up taking the 101 dalmatians and then Cruella along with them or Anita will be fired. Then Roger and Anita find out they aren't married.
Cruella finds out that she can steal the farm away from the Dearlys if they don't get married in 48 hours. So Cruella comes up with stunts to keep them from getting to the church in time. Including tricking Roger into signing a contract to play baseball.
The pups try their best to help Roger find Anita, who is held captive by alien cultists who refuse to let her leave until their Shaggy-Green Messenger comes for them.
