In 2262, longstanding conflicts between telepaths and normal humans lead to a major clash on the space station. A new captain takes over, and Sheridan continues Babylon 5's peacekeeping mission by forming the InterStellar Alliance.
Londo collapses from a heart attack, and must battle with his guilt in a dream state. Delenn learns that Lennier is planing to leave Babylon 5 to join the Rangers.
Bester arrives at the station to arrest the Downbelow telepaths, and Londo barely escapes an assassination attempt when the ship he was to be aboard explodes.
As more telepaths arrive at the station, the denizens of Downbelow start taking notice. Tensions build until one of the telepaths is assaulted, and the others decide to take revenge - against Byron's wishes. Meanwhile, Franklin tries to find out why the Hyach are hiding part of their medical history.
The Brakiri buy a part of Babylon 5 for a religious ceremony where the dead are supposed to return. Comedians Rebo and Zooty arrive to do a show on the station.
Londo starts to suspect that all is not right on Centauri Prime, when a good friend is murdered. On Babylon 5, Byron tries to force the council to give him and his telepaths a homeworld of their own.
The telepaths have barred themselves inside an area of Downbelow, and their telepathic tricks force Lochley to ask Bester for help. G'Kar finds an old friend locked in a cell in the Centauri palace.
More bloodhound units arrive and the fight with the violent faction of Byron's followers intensifies until the rogues seize Medlab - with Garibaldi and Franklin in it.
It looks like the Alliance will get a break in the investigation of the recent shipping line attacks, when a possible witness may have survived the latest attack and taken refuge on the Drazi homeworld. Garibaldi is sent to find him, but the Intelligence Chief's alcohol problem complicates the mission. G'Kar returns to Babylon 5 to discover that his book has been published, and he is now a revered religious figure.
A telepath murders his roommate and escapes on a ship bound for Babylon 5. Bester is given the job of capturing him, and brings along two PSI Cop interns to show them how he works.
Delenn reassigns Lennier to a Ranger training mission on the border of Centauri space, hoping he can find some proof regarding the Centauri involvement in the shipping line attacks. Vir undergoes some dramatic changes when he learns that he is the new Centauri ambassador to Babylon 5.
Lennier investigates Centauri signals that may be connected to the attacks. Lyta tries to continue Byron's dream of finding a homeworld for telepaths. Lise visits Garibaldi only to discover he's drinking again.
The evidence collected against the Centauri is presented to the council of the Interstellar Alliance, and a boycott against the Centauri is issued. In reaction, the Centauri withdraw from the Alliance and make it clear that they will circumvent the blockade by force if necessary.
Sheridan finally authorizes the White Star fleet to participate in the war. Delenn travels to Minbar to start a Minbari-Earth joint project to build a prototype White Star destroyer class ship. Vir hires Franklin and Lyta to investigate why the Drazi don't return the bodies from destroyed Centauri ships.
As Centauri Prime is being bombarded, the Drakh, the real masters behind the war, reveal themselves to Londo. They force him to go along with their plan to alienate the Centauri from the Alliance, and use what's left as their new home.
Earth Force orders the arrest of Lyta for financing terrorism against the PSI Corps. Sheridan confronts Garibaldi about his drinking. G'Kar struggles with his growing mass of worshippers.
Tessa Holloran, former Number One of the Mars resistance, arrives with a warning for Lise and Michael: an assassin has been hired to kill them. Meanwhile, G'Kar gets ready to leave, though not everybody is happy about it.
It is near the end of 2262, and many changes are abound. Londo, G'Kar and Garibaldi have already left, and Franklin will be taking up his new position on Earth shortly. Finally, Sheridan and Delenn leave for Minbar, where the Alliance's recently finished headquarters are located.
Twenty years after his death and resurrection at Z'ha'dum, Sheridan feels his life force ebbing away, and invites some old friends for a final gathering.
