Peter blows his savings on lottery tickets and the family writes it off as one of his usual shenanigans until they end up millionaires. In true Griffin fashion, they can’t handle the good fortune and struggle to stay grounded.
While the Griffins are housebound during a hurricane, Brian ingests psychedelic mushrooms. He sees bizarre and unsettling things, and acts accordingly. Meanwhile, the rest of the family is bored and irritable, and Meg finally lashes out at Chris, Lois and Peter for all the crap they've given her.
The crossover starts on The Cleveland Show S03E02 The Hurricane (I). It continues on American Dad! S08E02 Hurricane! (III).
Stewie tries to be a big boy and steals Brian's car for a joy ride but lands in a bit of trouble. Meanwhile, Ryan Reynolds visits Quahog and becomes obsessed with Peter.
Lois cooks a big Thanksgiving meal and invites the whole crew over for dinner, and Joe is shocked when his formerly M.I.A. son, Kevin Swanson, returns from Iraq.
On the return from an adventurous day at an amusement park, the Griffins’ car breaks down in Amish country and they are stranded with no way out. When Meg falls for an Amish boy, the Griffins then find themselves in a crusade against the conservative locals.
Peter and the guys take a stand against their wives and flee to the Deep South on a road trip. On their Deep South road trip, Peter and the guys earn a one-way ticket to jail, then decide to make a run for it.
It’s winter in Quahog, and Lois’ parents take Stewie away on a trip. But when Carter falls asleep at the wheel, the family decides it might be time for him to retire. Peter and Lois take the clan to Florida to check out some fine retirement communities, but Carter refuses to go down without a fight.
When Lois discovers that Stewie's sick playmate is being denied medical treatment because his parents are Christian Scientists, she decides to take matters into her own hands.
When Peter decides to become a famous actor, he becomes Tom Tucker's agent as his first step toward stardom. Meanwhile, Chris dates a girl who looks disturbingly like a member of the Griffin household.
Overwhelmed with financial troubles, Mort asks Peter and Quagmire to help him save his pharmacy. However, things take a turn for the worse when the trio decides to burn it down to collect insurance money
After a night out, Peter, Joe, Brian and Quagmire awake in a hospital and discover that they don't remember anything and that the town has been deserted.
