In the surgical department of Holby City Hospital, surgeons Anton Meyer and Nick Jordan race against time to carry out a heart transplant operation, but first they have to make the difficult choice between two possible recipients, Alan Kenyon and Simon Harwood.
Kirstie Collins, who is helping Muriel McKendrick with the trial of a new drug, finds a severe adverse reaction from a patient, and wants to alert the drugs company, but McKendrick warns her against doing so.
Nick Jordan helps a family to make a difficult decision, but he can't escape a clash with Karen Newburn over their troubled past, as well as an altercation with an ex-boyfriend of Ellie Sharpe's.
