In Naples, Italy, the suspected son of Joestar family arch nemesis Dio dreams of becoming a Gang Star so he can bring down the local mafia from within.
Koichi arrives in Italy on a mission from Jotaro to find Giorno; they meet haphazardly when Giorno steals Koichi's luggage, and the ensuing chase leads Giorno into a Stand battle with the gangster Leaky Eye Luca.
Bucciarati and Abbacchio are the only members of the gang left in the yacht. They have to find out where the enemy stand is hiding and how does it work.
Formaggio traps the now miniature Narancia beneath his foot and attempts to interrogate him, but Narancia resists. A flashback shows Narancia's early life on the streets and his rescue by Bucciarati.
In order to protect Trish from the Hitman Team, Bucciarati and crew's second mission from the boss was to go find a key in Pompei for some kind of vehicle that should aid them later on. Following orders, Giorno, Abbacchio, and Fugo head to Pompei to retrieve the key. When they get there, Fugo notices a suspicious shadow reflecting in a mirror that happened to be placed on one of the pillars there...
The person hiding in the mirror was Illuso from the Hitman Team. Fugo ends up being dragged into the mirror by Illuso's Stand, Man in the Mirror. Fugo then summons his own Stand, Purple Haze. Despite Giorno wanting to find Fugo, Abbacchio decides to go look for the key, since that was their mission. However, once Abbacchio finds the key, he also gets dragged into the mirror world...
"Take Trish to Venice." With their next order from the boss, Bucciarati and his crew head to Naples Station. "Use the key at the water fountain with the turtle on the 6th platform." They find the water fountain, but can't find the place to use the key. Meanwhile, Proscuitto and Pesci from the Hitman Team follow Bucciarati and the others to Naples Station. Bucciarati figures out the mystery behind the key and gets on the express train to Florence, and Proscuitto and Pesci follow.
The Grateful Dead slowly begins to age everybody on the train. With his teammates affected, Mista goes alone to confront the enemy, only to encounter Pesci and his Beach Boy.
Number Six from Sex Pistols manages to warn Bucciarati about the enemies and fights back, but The Grateful Dead's powers are taking a toll on him. Bucciarati steels his resolve and throws himself out with Prosciutto out of the train that's going 150kph. Barely hanging onto life, Prosciutto uses The Grateful Dead again. Pesci decides to take Prosciutto's resolve to heart and attacks Bucciarati.
After defeating Proscuitto and Pesci, Bucciarati and the others head to Venice in a car. Melone from the Hitman Team finds some of Bucciarati's blood at the scene where the train had stopped and then activates Babyface. The powerful remote-control Stand created by assaulting a woman on the train then goes after Bucciarati.
Using Babyface's Stand's ability to turn human parts into other things, Giorno uses his Golden Wind to make parts for the human body. He rebuilds his own body and fights back. Meanwhile, another member of the Hitman Team who's also after Trish, Ghiaccio, was trying to regroup with Melone and was driving to Giorno's location.
Ghiaccio's Stand, White Album is able to envelop him like a bodysuit and able to freeze everything around him to extremely low temperatures. Giorno and Mista somewhat make it to Venice, despite being partially frozen by Ghiaccio. But in order to try to get away from Ghiaccio, Giorno drives their car into the canal and they get stuck. Mista tries to sacrifice himself, but Giorno tells him that what's important right now isn't for him to sacrifice himself but for him to have resolve.
Mista and Giorno were able to defeat Ghiaccio. They then confirm the mission on the disc and head to the location they're supposed to take Trish. Bucciarati goes up the tower with Trish, but while they're in the elevator, Trish suddenly disappears. Bucciarati then realizes what the boss's true motives are.
Bucciarati finds out that the boss's true motive is to eliminate Trish because of her relationship with him, causing him to betray the boss and save Trish. Meanwhile, Giorno feels something bizarre is going on as they waited for Bucciarati's return. The boss's Stand, King Crimson rises.
Because of their own wills and their sense of justice, Bucciarati and the others end up betraying the organization. Trish also wants to find out who her father truly is, so she tells the others that her mother met her father in Sardinia. They all decide to have a meal in Venice before they leave and Narancia is suddenly attacked by a Stand. The boss's own personal elite guard was now on the move.
The Stand that attacked Narancia was named Crush and belonged to Squallo, a member of the boss's elite guard. On top of that, Narancia suddenly can only say the exact opposite of what he's thinking, thanks to the ability of Talking Mouth, the Stand of Squallo's partner, Tiziano. Using Narancia, Squallo and Tiziano throw the team into chaos. The two elite guard members put Narancia in danger, but he boldly faces them so they can get out of Venice safely.
After defeating Squallo and Tiziano, Bucciarati and the others head off to Sardinia to find out about the boss's past. They head to Marco Polo International Airport in order to get a jet, but a strange man was following them. Mista manages to kill the strange Stand user before they're able to call upon their Stand. Even though they're a bit put off at how simple that was, they get onto the jet and fly off. But once they're on the jet, Giorno hears a weird noise...
Trapped in the cabin of a flying plane with Notorious B.I.G, Trish has noticed that Giorno's brooch is turning into a brand new hand that will allow him to regain his powers. However, the movement of the transformation is attracting the enemy Stand. As the plane approaches the Tyrrhenian Sea, Trish must now try to protect both the hand of Giorno and herself from Notorious B.I.G.
On the island of Sardinia, a boy named Doppio is searching for Trish and the others on orders from Passione's boss. But Doppio has a dark secret, one that becomes apparent when he encounters Risotto of La Squadra.
Doppio, the alter ego of Passione's boss, continues to fight against Risotto and his iron controlling Metallica. Doppio struggles against the powerful assassin, but is armed with King Crimson's Epitaph, which allows him to see the future.
In the aftermath of the battle between Risotto and Doppio, Abbacchio uses Moody Blues to try and uncover the boss's identity. But the boss is adamant about keeping his identity a secret and executes his next gambit against the group.
After his death, Abbacchio was able to leave the others a copy of the boss’s face and fingerprints with Moody Blues' replay. The others try to find out who the boss is with the fingerprint and suddenly get contacted by someone. The mysterious man tells them that the boss’s name is Diavolo and tells them that the secret behind defeating him lies in the arrow. Bucciarati and the others head to Rome to meet him.
The gang are under attack by the last two members of the Elite Squad. Cioccolata uses his Green Day to spread a toxic mold over the island while Secco uses Oasis to swim through rock for stealth attacks, leaving the gang in a pinch.
While Bruno stays on the ground to fight against Secco's Oasis, Giorno and Mista head upwards towards Cioccolata to stop the power of his Green Day. But Cioccolata has another dangerous trick up his sleeve, pushing the two into a corner.
Everyone continues to desperately chase after the Requiem in order to obtain the Stand arrow. Diavolo's soul is then forced to show itself, but he will not quit until he obtains the arrow for himself.
In the past, Bruno and his team investigated the mysterious death of a girl and how it ties into the power known as Rolling Stones. And in the present, the final fate of Giorno and the gang is revealed as Golden Wind comes to a close.
