Two dysfunctional flatmates, Mark and Jeremy, fumble through work, love, and life in South London, with their awkward thoughts laid bare in the show’s signature point‑of‑view style.
Mark and Jeremy find themselves in competition for the same woman: Toni from next door. This is not the entire problem with Mark and his love life, rather, he is also lusting after Sophie, a co-worker, but finds himself at a loss with how to put his feelings into action. Jeremy is also pre-occupied, but not with love, with his music.
Jeremy faces a dilemma: money vs. art. Should he put all his time and effort into his music and try to 'make it' or should he be like Mark and get a 9 to 5 job to pay the bills (including three months of rent owed to Mark). Sophie is still the object of Mark's desires and he still fumbles about trying desperately to let her know how he feels.
Mark and Jeremy go to a party to try and find some long lost love, or perhaps someone for the night. At the party Mark meets a cool goth 'teenager' named Valarie, who wants to take their acquaintance to the next level: bowling! This gives Jeremy a chance to hook up with Toni, and allows Mark to take his mind off of Sophie . . . or will it?
Mark attends a work conference and in the process makes a new friend, Alan Johnson, which upsets the 'El Dude' partnership. This forces Jeremy to consider who could replace Mark as flatmate and best friend. Super-Hands is the potential replacement, but he doesn't match up as well. Mark grows a moustache, like his new hero, Johnson whilst Jeremy is haunted by flashbacks to 'the one bad thing' that happened when he was wrecked with Super-Hands.
Jeremy tries to wow Toni with his new job in a music studio while Mark gets passed over for promotion in favour of Sophie, and goes slowly round the twist. They then attempt to solve each other's problems with the help of phone stalking and pepper spray.
In the last episode of the series, death and terminal illness prove to be the keys to romantic success for Mark and Jeremy. Jeremy gets in with the Christians and Mark finds the perfect venue for a first date with Sophie - a funeral. Everyone's having a great time until the paramedics arrive.
