Brain hatches a plot to hypnotize people, but he needs white crab meat to succeed. In order to get the crab meat, he takes a submarine to the wreck of the Titanic. Unfortunately, the CIA spots his sub and orders its destruction.
Brain plans to take over the world by creating a voice mail system that will tie up everyone on the planet long enough for him to take over. In order to do this he needs money. He decides to get it by getting a job and then staging an accident in order to sue the company.
Brain uses an enlarging ray to make himself and Pinky four hundred feet tall. With Pinky dressed as a Gollyzilla, Brain stages a fight to make himself look like hero. But then the real Gollyzilla shows up.
Brain gains the ability to cloud the minds of men with his voice. He tries to get on the radio by adapting the persona of "The Fog". Unfortunately his plan falls apart when he gets to the studio.
Brain hears that a space probe is about to be launched. On the probe is a plaque with a representation of man and woman. Brain changes the plaque to make it appear that he rules the world. Aliens discover the probe and take Pinky and the Brain to their planet where they honor them just like they are "honored" on Earth.
The Brain hatches a plan to take over the world by using static electricity to shock the world into submission. Unfortunately he needs several billion dollars to build a giant clothes dryer. Pinky and the Brain head to Island X where they set up a fake country and hope to get a giant foreign aid loan from the United States.
Brain develops a special pair of dentures that can produce a smile that can hypnotize anyone who is not wearing a special pair of sunglasses. In order to take over the world, he needs people to see the mesmerizing smile. He figures that he needs to get on TV and in order to do that he has to become a celebrity.
While France awaits Napoleon's triumphant return from Austria, Brain develops a recipe for exploding crepe-suzettes in an effort to conquer France. He uses the recipe in a cooking class and when the crepes explode, he is arrested. When he is taken to prison, however, his luck begins to change when people mistake him for Napoleon Bonaparte.
Pinky and the Brain head to the North Pole. Pinky just wants to see Santa, but the Brain has a more sinister plan. He wants pretend to be an elf so that he can mass produce a hypnotic doll named "Noddle Noggin" in Santa's workshop. He then hopes that Santa will distribute the toy all over world so he can take over.
In Victorian England, the Brain realizes that he can take over the world by becoming president of the "Pompous Explorers Club". since the position usually leads to the Prime Ministership of England. In order to become president of the club, he must make it around the world in seventy-nine days.
Brain hopes to take over the world by convincing everyone that Abraham Lincoln has been reincarnated. He takes up ventriloquism and plans on using a statue.
Pinky searches for the Brain in post-World War II Vienna. He misunderstands people when they try to tell him the Brain is dead and his misunderstandings lead to a series of misadventures.
