E1 · Owen Wilson with Kacey Musgraves
Owen Wilson hosts Saturday Night Live on October 2, 2021, with musical guest Kacey Musgraves.
E2 · Kim Kardashian West with Halsey
Kim Kardashian West hosts Saturday Night Live on October 9, 2021 with musical guest Halsey.
E3 · Rami Malek with Young Thug
Rami Malek hosts Saturday Night Live on October 16, 2021 with musical guest Young Thug.
E4 · Jason Sudeikis with Brandi Carlile
Jason Sudeikis hosts Saturday Night Live on October 23, 2021 with musical guest Brandi Carlile.
E5 · Kieran Culkin with Ed Sheeran
Kieran Culkin hosts Saturday Night Live on November 6, 2021 with musical guest Ed Sheeran.
E6 · Jonathan Majors with Taylor Swift
Jonathan Majors hosts Saturday Night Live on November 13, 2021 with musical guest Taylor Swift.
E7 · Simu Liu with Saweetie
Simu Liu hosts Saturday Night Live on November 20, 2021 with musical guest Saweetie.
E8 · Billie Eilish
Billie Eilish hosts and performs as the musical artist. Kate McKinnon returns presenting the CDC Players.
E9 · Paul Rudd
Actor and People's sexiest man of 2021 hosts.
E10 · Ariana DeBose with Bleachers
Ariana DeBose hosts Saturday Night Live on January 15, 2022 with musical guest Bleachers.
E11 · Will Forte with Måneskin
Will Forte hosts Saturday Night Live on January 22, 2022 with musical guest Måneskin.
E12 · Willem Dafoe with Katy Perry
Willem Dafoe hosts Saturday Night Live on January 29, 2022 with musical guest Katy Perry.
E13 · John Mulaney with LCD Soundsystem
John Mulaney hosts Saturday Night Live on February 26, 2022 with musical guest LCD Soundsystem.
E14 · Oscar Isaac with Charli XCX
Oscar Isaac hosts Saturday Night Live on March 5, 2022 with musical guest Charli XCX.
E15 · Zoë Kravitz with Rosalía
Zoë Kravitz hosts Saturday Night Live on March 12, 2022 with musical guest Rosalía.
E16 · Jerrod Carmichael with Gunna
Jerrod Carmichael hosts Saturday Night Live on April 2, 2022 with musical guest Gunna.
E17 · Jake Gyllenhaal with Camila Cabello
Jake Gyllenhaal hosts Saturday Night Live on April 9, 2022 with musical guest Camila Cabello.
E18 · Lizzo
Lizzo hosts and performs as musical guest on Saturday Night Live on April 16, 2022.
E19 · Benedict Cumberbatch with Arcade Fire
Benedict Cumberbatch hosts Saturday Night Live on May 7, 2022 with musical guest Arcade Fire.
E20 · Selena Gomez with Post Malone
Selena Gomez hosts Saturday Night Live on May 14, 2022 with musical guest Post Malone.
E21 · Natasha Lyonne with Japanese Breakfast
Natasha Lyonne hosts Saturday Night Live on May 21, 2022 with musical guest Japanese Breakfast.
