Detective Miller (M. Emmet Walsh) confronts toe removal specialist Dr. Stork (Bob Odenkirk) about some troubling inconsistencies with a medical waste investigation.
Tim, Eric and Zach are three weird guys who work and secretly live in the men's public restroom of the Stanton Building, where one day they run embarrassingly low on mints. Zach has a chance encounter at the candy store during his mint refill run, leading to a risky triple-date with the Bathroom Boys and three sisters from England.
Before his son's Sweet 17 party, Dan Dimler (Eric) is visited by Scotty Andrews (Tim), a hydrophobic young man who sells Dan his new DVD and enraptures him with his divine singing voice.
Hollywood actor and talented mixologist Franklin Bing (Tim) welcomes fellow actor and out of work barista Tony K. Dort (Eric) as his new roommate. Their initial friendship becomes increasingly strained as Franklin learns of Tony's erotic misadventures.
In order to protect his reputation and avoid low company, actor Jason Schwartzman strictly avoids product endorsement deals until his agent proposes a novel arrangement where the entire photo shoot takes place while he is asleep. The endorsement appears to work great until Jason realizes how the photos were absurdly manipulated.
Jordan Terp (John C. Reilly) answers an ad for a baby-based personal development program but is instead robbed of all his possessions by a pair of con artist brothers (Tim & Eric) posing as life coaches.
Mild-mannered family man Gary Royce has an...unconventional addiction. Mobster Bobby Bologna has a cure for his problem, but it comes at the price of Gary having to serve the mob as their Sauce Boy, in exchange for receiving the cure for his addiction, a "juice" which must be administered orally several times daily. Gary's duties as Sauce Boy include picking up po'boy sandwiches and dry cleaning for the mobsters, sweeping the bird-durd off the stoop of their social club, and preparing a meatless Italian red sauce (likely a sugo rather than a marinara) each day. Gary's...
