The four-year-old adopted son of a celebrity couple is kidnapped, and the team must determine if the reason has to deal with the parents' status or the boy's own Sudanese origin.
Malone's team joins forces with Gil Grissom, a CSI from Las Vegas, and his team as they track a serial killer with ties to New York.
The crossover starts on CSI: Crime Scene Investigation S08E06 Who and What (I).
The team determines if an ex-con's past criminal activity caused her to disappear after visiting a prison inmate. Det. Mars and Agent Johnson also continue their investigation.
Jack goes missing after taking a case into his own hands which soon becomes intertwined with a human trafficking prostitution case that Vivian is working on.
While struggling to deal with the aftermath of Jack's accident, the team searches to find a teen heart transplant recipient, believing her disappearance might be connected to her donor. Samantha talks to Brian.
A truck driver goes missing after saving a boy's life, and the team determines if that has anything to do with his disappearance. Meanwhile, Jack's mental health is examined by a psychiatrist.
Five people with an odd connection go missing from a coffee shop, and the team determines what the connection had to do with their disappearance. Meanwhile, Samantha gets ready for the birth of her child.
